Importantly, this proliferative effect of DIM happens with potentially physiological concentrations that can be provided by the diet or by taking caplet supplements. We document an unexpected effect of DIM on cell proliferation, which is to stimulate growth by inducing the ERα signaling pathway. 50 μM) have an opposite and expected effect on cells, which is to inhibit proliferation. In contrast, higher concentrations of DIM (e.g. DIM - is found in vegetables like broccoli and is available as a supplement in health food stores. We further show that the protein kinase A signaling pathway participates in DIM-mediated activation of ERα. 7 The power of diindolylmethane 8 Diindolylmethane and breast cancer: the evidence 9 Diindolylmethane and prostate cancer: the evidence 10 What else does diindolylmethane do 11 The Tonic DIM supplement 11.1 Special Tonic Vege Detox 50 Caps 11. One dietary supplement that is thought to have potential for BRCA1 carriers is diindolylmethane (DIM), which is an active ingredient in broccoli and other green vegetables. By using an ERα specific inhibitor (ICI 182 780), we confirm that the transcriptional and proliferative effects of DIM treatment are mediated by ERα. The estrogen levels are responsible for a lot of actions in the body. It keeps pre-menstrual and menopause symptoms in check. It works best for the prevention of breast, uterine and colon cancer. Accordingly, we observe induction of ERα target genes such as GREB1 and TFF1, and an increase in cellular proliferation after treatment with 10 μM DIM in the absence of E2. DIM Supplements are compounds found in cruciferous vegetables. In this study, we report that 'physiologically obtainable' concentrations of DIM (10 μM) activate the estrogen receptor α (ERα) signaling pathway in the human breast cancer cell lines MCF7 and T47D, in a 17β-estradiol (E2)-independent manner. We further make use of growth assays, as well as fluorescence-activated cell sorting (FACS) assays, to monitor cell growth. Here we make use of RNA expression assays coupled to Chromatin Immunoprecipitation (ChIP) in breast cancer cell lines to study the effect of DIM on estrogen signaling. It is commonly found in broccoli, and holds promise as being a molecule for anti-cancer effects and as an aromatase inhibitor. DIM (diindolylmethane) and Tamoxifen Interactions in Breast Cancer.
It is also used to prevent an enlarged prostate (benign prostatic hypertrophy, BPH) and treat premenstrual syndrome (PMS). The few studies done to date comparing glucobrassicin-rich crucifers such as Brussels sprouts with I3C/DIM supplements have shown the greater impact of the latter is due to dose.
#Dim supplement breast cancer driver
It is also advertised as a compound that regulates sex hormone homeostasis. Diindolylmethane is used for preventing breast, uterine, and colorectal cancer. Alteration of cytochrome P450-dependent estrogen metabolism is hypothesized to be an important driver of DIM-dependent breast cancer prevention. DIM is an aryl hydrocarbon receptor (AhR) ligand and a potential anticancer agent, namely for the treatment of breast cancer. 3,3'-diindolylmethane (DIM) is an acid-catalyzed dimer of idole-3-carbinol (I3C), a phytochemical found in cruciferous vegetables that include broccoli, Brussels sprouts and cabbage.
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